Vancomycin pulmonary penetration



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Early studies demonstrated linear pharmacokinetics with a dose proportional increase in AUC after intravenous doses up to the usual therapeutic dose of mg. Since its introduction linezolid has maintained excellent activity [ 34 , 35 ]. Vancomyci n concentration s i n serum , lun g tissu e an d th e ratio s o f lun g tissu e t o seru m. Department of Thoracic Surgery;. Vancomyci n penetratio n int o lun g tissu e wa s evaluate d i n thirt y patient s followin g. Therefore, a more appropriate modality of administration, such as continuous infusion, should be considered. National Library of Medicine Rockville Pike , Bethesda MD , USA.
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Nosocomial methicillin-resistant staphylococcus aureus (MRSA) pneumonia: linezolid or vancomycin? - Comparison of pharmacology and clinical efficacy


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Potential impact of vancomycin pulmonary distribution on treatment outcomes in patients with methicillin-resistant Staphylococcus aureus pneumonia

Cite article How to cite? Linezolid is besides vancomycin currently the only of the novel drugs with MRSA-activity that is approved for the treatment of nosocomial pneumonia in the USA and Europe, including cases caused by MRSA. Nonetheless, relationship between increased MIC and treatment success or failure in serious Staphylococcus aureus infections has recently been established.
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